EPA Bloodborne Pathogens List 2024
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Last significant update: August 31, 2026

EPA List S: Disinfectants Effective Against Bloodborne Pathogens

Disinfectant reference

What Is EPA List S?

EPA List S is the Environmental Protection Agency’s current reference for EPA-registered antimicrobial products effective against the bloodborne pathogens HIV, hepatitis B, and hepatitis C. It combines information previously maintained across several separate disinfectant lists, making it easier to verify a product by its EPA registration number and label directions.

Former List C Products effective against human HIV-1.
Former List D Products effective against HIV-1 and hepatitis B.
Former List E Products previously listed for tuberculosis, HIV-1, and hepatitis B.
Former List F Products effective against hepatitis C.
Use the live EPA list, not a copied product list: registrations, labels, and directions can change. EPA directs users of the former lists to current List S. List S concerns HIV, hepatitis B, and hepatitis C; products registered for tuberculosis efficacy are covered separately by EPA List B.

Product verification process

How to Check Whether a Product Is on EPA List S

Use the EPA registration number and the product label together. A product name alone is not always enough to confirm the exact formulation, approved surface, pathogen coverage, or directions for use.

1

Find the EPA Registration Number

Check the product label for “EPA Reg. No.” and record the registration number exactly as shown. See EPA’s disinfectant-list guidance for an example.

2

Recognize Distributor Numbers

Supplemental distributor products may add a third number to the primary EPA registration number. For example, a product labelled 12345-12-2567 may correspond to primary registration 12345-12.

3

Search List S by Registration

Search the live EPA list using the primary registration number. This is more reliable than relying on a similar product name or packaging design.

4

Confirm the Label Directions

Check that the label covers the relevant pathogen and states directions for disinfection, including the approved surface, use site, application method, and required wet contact time.

Registration is not a blanket approval: even where a product appears on List S, always follow the directions on the label for the specific pathogen and setting. A product may have different contact times—or no listed efficacy—for one or more pathogens.

How to Use Products on the Bloodborne Pathogens List Effectively

A disinfectant is only effective when it is used exactly as its EPA-registered label directs. Products can have different directions and contact times for HIV, Hepatitis B, and Hepatitis C, so check the label for the relevant pathogen before using it.

Step 1

Choose the Relevant Claim

Check the product’s listed efficacy for the pathogen relevant to your cleanup procedure. A List S entry may show a claim for all three viruses, only some of them, or “N/A” where a claim is not listed.

Step 2

Keep the Surface Wet

Contact time is the period the disinfectant must remain wet on the surface to work effectively. Follow the label’s stated time for the specific pathogen rather than assuming one time applies to every use.

Step 3

Follow the Full Label

Also confirm the product is suitable for the surface, use site, and application method. Dilution, pre-cleaning, ventilation, and PPE instructions can all affect safe and effective use.

For blood or OPIM spills: selecting an appropriate disinfectant is only one part of the process. Review our practical guide to bloodborne pathogen cleanup procedures for containment, PPE, waste disposal, and safe handling steps.

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